HCID 86625622, compound → Stavudine

HRID 913265

Reaction equation

HRID 913265 reaction equation
[CH3:1][C:2]1[C:8](=[O:9])[NH:7][C:5](=[O:6])[N:4]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[CH:12]=[CH:11]2)[CH:3]=1.CN1C(=O)N(C)CCC1>O>[C@@H:10]1([N:4]2[CH:3]=[C:2]([CH3:1])[C:8](=[O:9])[NH:7][C:5]2=[O:6])[O:14][C@H:13]([CH2:15][OH:16])[CH:12]=[CH:11]1

Participants

3

Reactant 1

HCID 86625622HCID 86625622, compound

Product 1

HCID 18283StavudineYield 66.82%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
2.5 °C

Procedure

Stavudine DMPU solvate (20 g, 0.057 mole) is dissolved in water (20 ml) at 55° C. and the solution is allowed cooling on its own for an hour to crystallize. The mixture is further cooled on 0-5° C. for 2 hrs. The precipitated product is filtered, washed with acetone and dried to give 8.5 g (66.82%) of pure white crystalline Stavudine. HPLC results are given in Table-2

Workup

  1. temperaturethe solution is allowed cooling on its own for an hour
  2. customto crystallize
  3. filtrationThe precipitated product is filtered
  4. washwashed with acetone
  5. customdried

Sources & evidence

ORD record
ord-c22b27eb05fb4b52934752f5d42be106
Source dataset
uspto-grants-2011_09
Patent number
US08026356B2

Linked notes

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