5-(Chloromethyl)-3-phenylisoxazole → HCID 67405206, compound

HRID 913646Notes

Reaction equation

HRID 913646 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.Cl[CH2:17][C:18]1[O:22][N:21]=[C:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:19]=1>>[C:23]1([C:20]2[CH:19]=[C:18]([CH2:17][N:7]3[C:8]4[C:4](=[C:3]([C:2]([F:14])([F:1])[F:15])[C:11]([C:12]#[N:13])=[CH:10][CH:9]=4)[CH:5]=[CH:6]3)[O:22][N:21]=2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 27640575-(Chloromethyl)-3-phenylisoxazoleHCID 674054494-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 67405206HCID 67405206, compound

Procedure

Synthesized in a manner similar to Example 23 using 4-(trifluoromethyl)-1H-indole-5-carbonitrile and 5-(chloromethyl)-3-phenylisoxazole: MS (ES) m/z 368 (M+1).

Sources & evidence

ORD record
ord-405f254230894f519f7293b2353e5ee3
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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