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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913751Generated: October 26, 2026

(3,5-Difluorophenyl)boronic acid → 2-Cyclopropyl-1-{[5-(3,5-difluorophenyl)-2-furanyl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913751

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3,5-Difluorophenyl)boronic acidHCID 2734338—
Reactant1-[(5-Bromo-2-furanyl)methyl]-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404993—
Product2-Cyclopropyl-1-{[5-(3,5-difluorophenyl)-2-furanyl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405041—

Reaction Steps

Synthesizes as described in Example 310D using (1-[(5-bromo-2-furanyl)methyl]-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 310C) and (3,5-difluorophenyl)boronic acid: MS (ES) m/z 443 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-38f59caf1ca14188ad9746f3a645698f
Source noteuspto-grants-2011_09