HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(6-(3-(2-Fluorophenyl)aminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Fluorophenyl isocyanate | HCID 85588 | — |
| Reactant | 1-(6-(3-Aminopropanoyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985556 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(6-(3-(2-Fluorophenyl)aminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985574 | 26% |
Reaction Steps
Similar to the synthesis of Example 249, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 2-fluorophenyl isocyanate in DMF was reacted to give the desired compound 0.022 g (26%). LC/MS 430.01 (M+1); LC retention time 2.89 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091227B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-8af57543031d410a83801cfb7baaad6c |
| Source note | uspto-grants-2006_08 |