Aluminium lithium hydride → [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol

HRID 915449Notes

Reaction equation

HRID 915449 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH2:22][C:23]([F:26])([F:25])[F:24])[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[CH:10]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:25][C:23]([F:24])([F:26])[CH2:22][N:7]1[C:6]([CH2:4][OH:3])=[CH:10][C:9]([C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:19])([F:20])[F:21])=[CH:15][CH:16]=2)=[N:8]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 866006282-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

Product 1

HCID 86600629[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol

Procedure

In analogy to the procedure described for example 1 a], 2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester was reduced with lithium aluminium hydride to give [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol as colorless solid.

Sources & evidence

ORD record
ord-8c02b4a2b9e64f52af4bd15ea4438023
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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