Sodium Hydroxide → [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetic acid
Reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]1[C:8]([CH2:9][C:10]#N)=[CH:7][C:6]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)=[N:5]1.[OH-:25].[Na+].[OH2:27].C(O)C>>[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]1[C:8]([CH2:9][C:10]([OH:27])=[O:25])=[CH:7][C:6]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)=[N:5]1Participants
4
Procedure
In analogy to the procedure described for example 9 c], [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile was treated with sodium hydroxide in water/ethanol 1/1 at 85° C. to give [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetic acid as brown crystals.