HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9156Generated: October 23, 2026
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → N-Ethyl-N'-(8-methyl-5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)urea
https://huagongshe.com/en/reaction/9156
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| Reactant | N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N'-ethylurea | HCID 21985605 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-Ethyl-N'-(8-methyl-5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)urea | HCID 21985619 | — |
Reaction Steps
To a suspension of N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N′-ethylurea in toluene is added DDQ (1.1 eq.). The reaction mixture is stirred at about 45° C. for about 4 hrs. The reaction mixture is pumped down and the crude material is purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07091227B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-2df8a4191bd44591b7d0af914e3af49b |
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| Source note | uspto-grants-2006_08 |
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