2-Amino-5-chlorobenzenesulphonamide → 7-Chloro-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

HRID 915741

Reaction equation

HRID 915741 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH:13]([O-])([O-])OCC>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][CH:13]=[N:12][S:9](=[O:11])(=[O:10])[C:3]=2[CH:4]=1

Participants

3

Reactant 2

HCID 122955502-Amino-5-chlorobenzenesulphonamideHCID 53630039Ethylorthoformate

Product 1

HCID 100362767-Chloro-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Conditions

Temperature
110 °C

Procedure

40 ml of ethyl orthoformate are added to 4.75 g of 2-amino-5-chlorobenzenesulphonamide, the preparation of which is described in the journal J. Chem. Soc. Perkin I 1979, 1043-1047. The mixture is heated at 110° C. for 30 minutes in an open vessel. Dissolution is observed, and then the appearance of a precipitate.

Workup

  1. customthe preparation of which
  2. dissolutionDissolution

Sources & evidence

ORD record
ord-8c5508e013dd46e7967bc5c34389410b
Source dataset
uspto-grants-2007_09
Patent number
US07268129B2

Linked notes

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