HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9162Generated: October 26, 2026
Piperazine → N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-(3-piperazinopropyl)urea
https://huagongshe.com/reaction/9162
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | N-(6-bromo-1,3-benzothiazol-2-yl)-N'-(3-chloropropyl)urea | HCID 21985572 | — |
| Solvent | Tetrahydrofuran ethanol | HCID 21873804 | — |
| Product | N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-(3-piperazinopropyl)urea | HCID 21985562 | — |
Reaction Steps
To a mixture of N-(6-bromo-1,3-benzothiazol-2-yl)-N′-(3-chloropropyl)urea (100 mg, 0.287 mmol) in THF/EtOH (0.50/0.25 mL) was added piperazine (247 mg, 2.87 mmol). The reaction mixture was heated to about 55° C. for about 16 hrs. The crude reaction mixture was pumped down and purified by flash chromatography on SiO2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07091227B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-8cc7371e38f3460581b5e22886eb5510 |
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| Source note | uspto-grants-2006_08 |
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