N,N-Diethylpiperidine-3-carboxamide → 1-(4-Cyanonaphthalen-1-yl)piperidine-3-carboxylic acid diethylamide
Reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[CH2:14]([N:16]([CH2:25][CH3:26])[C:17](=[O:24])[CH:18]1[CH2:23][CH2:22][CH2:21][NH:20][CH2:19]1)[CH3:15]>N1C=CC=CC=1>[CH2:25]([N:16]([CH2:14][CH3:15])[C:17]([CH:18]1[CH2:23][CH2:22][CH2:21][N:20]([C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:19]1)=[O:24])[CH3:26]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 1-cyano-4-fluoronaphthalene in pyridine (0.6 M, 1 mL) was transferred to a Pyrex tube and N,N-diethylnipecotamide (447 mg, 2.4 mmol) was added. The tube was capped and the reaction tube was exposed to microwave irradiation (220° C., 10 min). The reaction mixture was concentrated and purified according to Purification Method A.