Phenyl(piperidin-4-yl)methanone → 4-(4-Benzoylpiperidin-1-yl)naphthalene-1-carbonitrile
Reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[C:14]([CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:14]([CH:22]1[CH2:27][CH2:26][N:25]([C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:24][CH2:23]1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1Participants
3
Procedure
The title compound (3 mg, 8% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 4-benzoylpiperidine (89 mg, 0.468 mmol).
Sources & evidence
- ORD record
- ord-3c0b9d2cd4114abf8c04a3daba38762c
- Source dataset
- uspto-grants-2007_09