4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine → (4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)-methanone

HRID 916779

Reaction equation

HRID 916779 reaction equation
ClC1C2C=CN(C)C=2N=CN=1.[NH2:12][C:13]1[C:14]2[C:21]([C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([NH2:30])[CH:25]=3)=[O:23])=[CH:20][N:19]([CH:31]3CCCC3)[C:15]=2[N:16]=[CH:17][N:18]=1>>[NH2:12][C:13]1[C:14]2[C:21]([C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([NH2:30])[CH:25]=3)=[O:23])=[CH:20][N:19]([CH3:31])[C:15]=2[N:16]=[CH:17][N:18]=1

Participants

3

Reactant 2

HCID 2658294-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidineHCID 11859044(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)methanone

Product 1

HCID 67219490(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)-methanone

Procedure

The title compound was prepared from 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidin by procedures analogous to those described for the preparation of (4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)-methanone. MS: 268.1 (MH+); HPLC Rf: 3.17 min. (HPLC method 4); HPLC purity: 92%.

Sources & evidence

ORD record
ord-05b7064c210348dbad9e920be139e1ba
Source dataset
uspto-grants-2007_09
Patent number
US07271262B2

Linked notes

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