(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)methanone → 4-[4-Amino-5-(3-amino-benzoyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 916785

Reaction equation

HRID 916785 reaction equation
[C:1]([O:5][C:6]([N:8]1CCC(N2C3N=CN=C(Cl)C=3C=C2)CC1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:24][C:25]1[C:26]2[C:33]([C:34]([C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([NH2:42])[CH:37]=3)=[O:35])=[CH:32][N:31]([CH:43]3[CH2:47][CH2:46][CH2:45][CH2:44]3)[C:27]=2[N:28]=[CH:29][N:30]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:46][CH2:47][CH:43]([N:31]2[C:27]3[N:28]=[CH:29][N:30]=[C:25]([NH2:24])[C:26]=3[C:33]([C:34](=[O:35])[C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([NH2:42])[CH:37]=3)=[CH:32]2)[CH2:44][CH2:45]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 11859044(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)methanoneHCID 58270310tert-butyl 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidine-1-carboxylate

Product 1

HCID 672197434-[4-Amino-5-(3-amino-benzoyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-piperidine-1-carboxylic acid tert-butyl ester

Procedure

The title compound was prepared from 4-(4-Chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-piperidine-1-carboxylic acid tert-butyl ester by procedures analogous to those described for the preparation of (4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)-methanone. MS: 437.5 (MH+); HPLC Rf: 5.18 min. (HPLC method 4); HPLC purity: 100%.

Sources & evidence

ORD record
ord-acc5168f6a454086a4001f9bf53262ca
Source dataset
uspto-grants-2007_09
Patent number
US07271262B2

Linked notes

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