Iodine chloride → 3-Chloro-4-amino-5-iodobenzylamine

HRID 917554

Reaction equation

HRID 917554 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[NH2:10])[CH2:5][NH2:6].[I:11]Cl>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([I:11])[C:9]=1[NH2:10])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 24640Iodine chlorideHCID 218806504-(Aminomethyl)-2-chloroaniline

Product 1

HCID 589629913-Chloro-4-amino-5-iodobenzylamineYield 42%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 3-Chloro-4-aminobenzylamine (200 mg, 1.28 mmol) in methanol (5 mL) was added Iodine monochloride (230 mg, 1.42 mmol). The mixture was stirred for 1 hour, then purified by HPLC to give 3-chloro-4-amino-5-iodobenzylamine (150 mg, 42%).

Workup

  1. custompurified by HPLC

Sources & evidence

ORD record
ord-c91c441261634aabb7976c3ccf95dde8
Source dataset
uspto-grants-2007_09
Patent number
US07273882B2

Linked notes

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