Azelaic Acid → Bis(2-hydroxyethyl) azelate

Participants

Reaction Steps

The reaction of 0.25 moles azelaic acid with 0.55 moles ethylene oxide under pressure using methyl isobutyl ketone in the presence of the catalyst of Example II(0.15% by wt. of total system) at 153°C gave bis(2-hydroxy ethyl)azelate in quantitative crude yield. The material was isolated as a grey-white solid melting at 46°-47°C from a n-butyl chloride-acetone mixture in 88.5% yield.

Provenance & Evidence