(4-Bromo-2-methyl-2H-pyrazol-3-yl)-(6-phenyl-pyridin-2-yl)-amine → 1-{4'-[1-Methyl-5-(6-phenyl-pyridin-2-ylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

HRID 919084

Reaction equation

HRID 919084 reaction equation
Br[C:2]1[CH:6]=[N:5][N:4]([CH3:7])[C:3]=1[NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1.[CH2:21]([O:23][C:24]([C:26]1([C:29]2[CH:34]=[CH:33][C:32]([C:35]3[CH:40]=[CH:39][C:38](B4OC(C)(C)C(C)(C)O4)=[CH:37][CH:36]=3)=[CH:31][CH:30]=2)[CH2:28][CH2:27]1)=[O:25])[CH3:22]>>[CH2:21]([O:23][C:24]([C:26]1([C:29]2[CH:30]=[CH:31][C:32]([C:35]3[CH:36]=[CH:37][C:38]([C:2]4[CH:6]=[N:5][N:4]([CH3:7])[C:3]=4[NH:8][C:9]4[CH:14]=[CH:13][CH:12]=[C:11]([C:15]5[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=5)[N:10]=4)=[CH:39][CH:40]=3)=[CH:33][CH:34]=2)[CH2:28][CH2:27]1)=[O:25])[CH3:22]

Participants

3

Reactant 2

HCID 67957971(4-Bromo-2-methyl-2H-pyrazol-3-yl)-(6-phenyl-pyridin-2-yl)-amineHCID 679580391-[4'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Product 1

HCID 679595651-{4'-[1-Methyl-5-(6-phenyl-pyridin-2-ylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 5, Step 2, using the following starting materials: (4-bromo-2-methyl-2H-pyrazol-3-yl)-(6-phenyl-pyridin-2-yl)-amine and 1-[4′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-03dafeba6cc64f70a3cdfef44672d10e
Source dataset
uspto-grants-2016_03
Patent number
US09272990B2

Linked notes

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