3-(Trifluoromethyl)phenylboronic acid → 2-(3-Fluoro-4-(3-(trifluoromethyl)phenoxy)phenyl)ethanol
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][OH:10])[CH:5]=[CH:4][C:3]=1[OH:11].[F:12][C:13]([F:24])([F:23])[C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1>>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][OH:10])[CH:5]=[CH:4][C:3]=1[O:11][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]([C:13]([F:24])([F:23])[F:12])[CH:19]=1Participants
3
Procedure
The title compound was prepared by a procedure similar to that described for D120 starting from 2-fluoro-4-(2-hydroxyethyl)phenol and (3-(trifluoromethyl)phenyl)boronic acid.
Sources & evidence
- ORD record
- ord-8b590d88d33943f3b43a20541d0ab770
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09273054B2
Reaction notes
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