(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol → 8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920367

Reaction equation

HRID 920367 reaction equation
Cl[C:2]1[CH:12]=[C:6]2[N:7]([CH3:11])[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1.[Cl:14][C:15]1[CH:29]=[CH:28][C:18]([O:19][C:20]2[CH:25]=[CH:24][C:23]([CH2:26][OH:27])=[CH:22][CH:21]=2)=[CH:17][C:16]=1[C:30]([F:33])([F:32])[F:31]>>[Cl:14][C:15]1[CH:29]=[CH:28][C:18]([O:19][C:20]2[CH:21]=[CH:22][C:23]([CH2:26][O:27][C:2]3[CH:12]=[C:6]4[N:7]([CH3:11])[CH2:8][CH2:9][CH2:10][N:5]4[C:4](=[O:13])[N:3]=3)=[CH:24][CH:25]=2)=[CH:17][C:16]=1[C:30]([F:31])([F:32])[F:33]

Participants

3

Reactant 2

HCID 66825563(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)methanolHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712366258-((4-(4-chloro-3-(trifluoromethyl)phenoxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and (4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol.

Sources & evidence

ORD record
ord-da00b3fb080246239d6634842721098b
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Linked notes

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