(6-Fluoropyridin-3-yl)boronic acid → 4'-(6-fluoropyridin-3-yl)-1'-methylspiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 92188

Reaction equation

HRID 92188 reaction equation
[Br:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[N:8]([CH3:23])[C:9](=[O:22])[C:10]21[CH2:11][O:12][c:13]2[c:14]1[cH:15][c:16]1[c:17]([cH:21]2)[O:18][CH2:19][O:20]1.[Br:24][c:25]1[cH:26][cH:27][cH:28][c:29]2[c:55]1[C:43]1([C:41](=[O:42])[N:30]2[CH2:31][c:32]2[o:33][c:34]([C:35]([F:36])([F:37])[F:38])[cH:39][cH:40]2)[CH2:44][O:45][c:46]2[cH:47][c:48]3[c:49]([cH:50][c:51]21)[CH2:52][CH2:53][O:54]3.[F:56][c:57]1[cH:58][cH:59][c:60]([B:63]([OH:64])[OH:65])[cH:61][n:62]1.[n:66]1[cH:67][c:68]([B:69]([OH:70])[OH:71])[cH:72][n:73][cH:74]1>>[c:2]1(-[c:60]2[cH:59][cH:58][c:57]([F:56])[n:62][cH:61]2)[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[N:8]([CH3:23])[C:9](=[O:22])[C:10]21[CH2:11][O:12][c:13]2[c:14]1[cH:15][c:16]1[c:17]([cH:21]2)[O:18][CH2:19][O:20]1

Participants

5

Reactant 4

HCID 2783397(6-Fluoropyridin-3-yl)boronic acidHCID 2795193(Pyrimidin-5-yl)boronic acidHCID 592634504'-bromo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-5,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-oneHCID 592634674'-bromo-1'-methylspiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Product 1

HCID 592634924'-(6-fluoropyridin-3-yl)-1'-methylspiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-c9c0221ba7bc40db862e6a4844104886
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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