Cyclopropylamine → Methyl (3-(5-(1-(cyclopropylamino)ethyl)-2-methoxypyridin-3-yl)prop-2-yn-1-yl)carbamate
Reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([C:12]#[C:13][CH2:14][NH:15][C:16](=[O:19])[O:17][CH3:18])[C:7]([O:10][CH3:11])=[N:8][CH:9]=1)(=O)[CH3:2].[CH:20]1([NH2:23])[CH2:22][CH2:21]1>>[CH:20]1([NH:23][CH:1]([C:4]2[CH:5]=[C:6]([C:12]#[C:13][CH2:14][NH:15][C:16](=[O:19])[O:17][CH3:18])[C:7]([O:10][CH3:11])=[N:8][CH:9]=2)[CH3:2])[CH2:22][CH2:21]1Participants
3
Procedure
Methyl [3-(5-acetyl-2-methoxypyridin-3-yl)prop-2-yn-1-yl]carbamate and cyclopropylamine were treated in the similar manner to Reference Example 6(6) to give methyl (3-{5-[1-(cyclopropylamino)ethyl]-2-methoxypyridin-3-yl}prop-2-yn-1-yl)carbamate [Ex(296-3)] as a colorless oil.
Sources & evidence
- ORD record
- ord-0e95973a2f3f4bfab74fa8ad51847864
- Source dataset
- uspto-grants-2016_03