4-Chloro-3-(pyridin-2-yl)aniline → N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonylmethyl)benzamide

HRID 922916

Reaction equation

HRID 922916 reaction equation
[CH2:1]([S:3]([CH2:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1)(=[O:5])=[O:4])[CH3:2].[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][C:18]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1>>[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH:21][C:11](=[O:13])[C:10]2[CH:9]=[CH:8][C:7]([CH2:6][S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])=[CH:15][CH:14]=2)=[CH:19][C:18]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1

Participants

3

Reactant 2

HCID 401519254-Chloro-3-(pyridin-2-yl)anilineHCID 434444454-(Ethylsulfonylmethyl)benzoic acid

Product 1

HCID 58614777N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonylmethyl)benzamide

Procedure

50 mg of 4-(ethylsulfonylmethyl)benzoic acid was coupled with 67 mg of 4-chloro-3-(pyridin-2-yl)aniline via Procedure G. This product was recrystallized from methanol to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonylmethyl)benzamide. MS (Q1) 415 (M)+.

Workup

  1. customThis product was recrystallized from methanol

Sources & evidence

ORD record
ord-35cbae17b5f64c69a047781d4535d70c
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Linked notes

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