HCID 14514526, compound → (2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Reaction equation
[N:1]1([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C@H:5]([C:6]([O:8]CC2C=CC=CC=2)=[O:7])[CH2:4][C@@H:3]2[CH2:16][CH2:17][CH2:18][C@H:2]12>CO.[OH-].[OH-].[Pd+2].[C]>[C:22]([O:21][C:19]([N:1]1[C@H:5]([C:6]([OH:8])=[O:7])[CH2:4][C@@H:3]2[CH2:16][CH2:17][CH2:18][C@H:2]12)=[O:20])([CH3:25])([CH3:23])[CH3:24]Participants
4
Procedure
To a solution of the product from Example 123A (0.56 g, 1.6 mmol) in MeOH (8.0 mL) was added Pd(OH)2/carbon. The mixture was evacuated and a H2 atmosphere was introduced via a balloon. The mixture was stirred overnight then filtered and the solvent was removed under reduced pressure to provide the title compound (0.42 g, 102% yield).