N-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine → N2-Methyl-5-(trifluoromethyl)pyridine-2,3-diamine
Reaction equation
[CH3:1][NH:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][C:6]([C:12]([F:15])([F:14])[F:13])=[CH:5][N:4]=1.[H][H]>[C].[Pd].C(O)C>[CH3:1][NH:2][C:3]1[C:8]([NH2:9])=[CH:7][C:6]([C:12]([F:15])([F:13])[F:14])=[CH:5][N:4]=1Participants
5
Procedure
A mixture of N-methyl-(3-nitro-5-trifluoromethyl-pyridin-2-yl)-amine (6.93 g), 5% of palladium-carbon (0.69 g), and ethanol was stirred under about 1 atm of hydrogen at room temperature for 10 hours. The reaction mixture was filtered through Celite®, and then the filtrate was concentrated under reduced pressure to give 5.02 g of N2-methyl-5-trifluoromethylpyridin-2,3-diamine (Compound (1F)-1).
Workup
- filtrationThe reaction mixture was filtered through Celite®
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-32202a0f687e44f18da50a49f4c82057
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09278983B2
Reaction notes
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