tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate → (R)-tert-butyl (1-(3-bromo-5-((4-(trifluoromethoxy)phenyl)carbamoyl)pyridin-2-yl)pyrrolidin-3-yl)(methyl)carbamate

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that in Stage 93.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.2) and (R)-tert-butyl methyl(pyrrolidin-3-yl)carbamate. LC-MS (Condition 6) tR=1.59 min, m/z=559.0/561.0 [M+H]+, m/z=502.9/504.9 [M+H—H2C═C(CH3)2].

Provenance & Evidence