Methyl 2-bromopropionate → (1Z)-1-[5-methyl-3-(5-methyl-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]ethyl]urea

HRID 924193

Reaction equation

HRID 924193 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[NH:11][C:12]([NH2:14])=[S:13])([CH3:3])[CH3:2].[N:15]([CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:30]=[CH:29][N:28]([C:31]3[CH:36]=[CH:35][C:34]([O:37][C:38]([F:41])([F:40])[F:39])=[CH:33][CH:32]=3)[N:27]=2)=[CH:22][CH:21]=1)=[C:16]=[O:17].Br[CH:43]([CH3:48])[C:44](OC)=[O:45]>>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[N:11]1[C:44](=[O:45])[CH:43]([CH3:48])[S:13]/[C:12]/1=[N:14]\[C:16]([NH:15][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:30]=[CH:29][N:28]([C:31]3[CH:36]=[CH:35][C:34]([O:37][C:38]([F:40])([F:39])[F:41])=[CH:33][CH:32]=3)[N:27]=2)=[CH:22][CH:21]=1)=[O:17])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 95576Methyl 2-bromopropionateHCID 893731681-(2-Isopropyl-5-methylphenyl)thioureaHCID 904044083-(4-(2-Isocyanatoethyl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole

Product 1

HCID 90404239(1Z)-1-[5-methyl-3-(5-methyl-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]ethyl]urea

Procedure

The title compound was prepared from 1-(2-isopropyl-5-methylphenyl)thiourea, 3-(4-(2-isocyanatoethyl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole (C34a), and methyl 2-brompropanoate and isolated as a clear sticky oil (0.192 g, 49%).

Sources & evidence

ORD record
ord-93783ffc4a11425aa169579c41ac229d
Source dataset
uspto-grants-2016_03
Patent number
US09278964B2

Linked notes

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