Chlorodiisopropylphosphine → HCID 178460690, compound

HRID 925042

Reaction equation

[C:1]([C:5]1[CH:23]=[CH:22][C:8]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([CH3:21])([CH3:20])[CH3:19])=[NH:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C([Li])CCC.Cl[P:30]([CH:34]([CH3:36])[CH3:35])[CH:31]([CH3:33])[CH3:32]>>[C:1]([C:5]1[CH:23]=[CH:22][C:8]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([CH3:21])([CH3:20])[CH3:19])=[N:10][P:30]([CH:34]([CH3:36])[CH3:35])[CH:31]([CH3:33])[CH3:32])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 3

HCID 538967Chlorodiisopropylphosphine

HCID 178418339Butyllithium

HCID 178440935HCID 178440935, compound

Product 1

HCID 178460690HCID 178460690, compound

Procedure

Procedure as described for NP Amidine I using the following amounts: 1.54 g of 4-tert-butyl-N1-(2-tert-butylphenyl)benzamidine (Amidine VII, 5.0 mmol), 2.50 mL of 2.0 M butyllithium (5.0 mmol), 0.80 mL chlorodiisopropylphosphine (5.0 mmol). After filtration to remove lithium chloride and removal of solvent, a yellow semi-solid was isolated (1.9 g, 100%).

Workup

filtrationAfter filtration
customto remove
customlithium chloride and removal of solvent
customa yellow semi-solid was isolated (1.9 g, 100%)

Sources & evidence

ORD record: ord-a7d2b1ae01704f778ef8d11870c35a07
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09283555B2

Linked notes

Loading…