HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → N-methacryloylglycylglycyl-thiazolidine-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Methacryloylglycylglycine | HCID 10241886 | — |
| Reactant | HCID 178527880 | HCID 178527880 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-methacryloylglycylglycyl-thiazolidine-2-thione | HCID 58455605 | — |
Reaction Steps
The synthesis of MA-GG-TT was similar to the synthesis of MA-GFLG-TT in Example 1. N-methacryloylglycylglycine (MA-GG-OH) was coupled with 2-mercaptothiazoline in DCM mediated by EDCI in presence of catalytic amount of DMAP. After reaction, the product was purified by recrystallization from MeOH solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09289510B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-7570d324d8d74bb897fc76c6c33cdc28 |
| Source note | uspto-grants-2016_03 |