3-nitro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole → 1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine

Participants

Reaction Steps

Into a 100-mL round-bottom flask, was placed a solution of 3-nitro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole (7 g, 27.24 mmol, 1.00 equiv) in methanol (30 mL). The mixture was treated with Pd/C (3 g) and stirred under a hydrogen atmosphere overnight at room temperature. The solids were filtered out. The resulting mixture was concentrated under vacuum to yield 6 g (97%) of 1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine as a white solid.

Provenance & Evidence