Methylamine hydrochloride → 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

HRID 927704

Reaction equation

HRID 927704 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([NH:14][C:15]([CH2:21][CH3:22])([CH2:19][CH3:20])[C:16]([OH:18])=O)=[O:13])[CH:9]=[CH:8][C:7]=2[C:23]([F:26])([F:25])[F:24])[CH2:3][CH2:2]1.Cl.[CH3:28][NH2:29]>>[CH2:21]([C:15]([NH:14][C:12]([C:10]1[CH:9]=[CH:8][C:7]([C:23]([F:24])([F:26])[F:25])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:13])([C:16](=[O:18])[NH:29][CH3:28])[CH2:19][CH3:20])[CH3:22]

Participants

3

Reactant 2

HCID 6364545Methylamine hydrochlorideHCID 710874622-(6-(Cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoic acid

Product 1

HCID 710935276-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 2-(6-(cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoic acid and methanamine hydrochloride as starting materials. MS (EI): m/e=388.0 [M+H]+.

Sources & evidence

ORD record
ord-db33cacc0f9e4225b2a38971a71608fb
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Linked notes

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