5-Bromo-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid → 5-Bromo-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-thiazol-2-yl-oxetan-3-yl)-amide

HRID 927728

Reaction equation

HRID 927728 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:14]([OH:16])=O)=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].Cl.[S:18]1[CH:22]=[CH:21][N:20]=[C:19]1[C:23]1([NH2:27])[CH2:26][O:25][CH2:24]1>>[S:18]1[CH:22]=[CH:21][N:20]=[C:19]1[C:23]1([NH:27][C:14]([C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[C:7]([O:8][CH2:9][C:10]([F:11])([F:12])[F:13])[N:6]=2)=[O:16])[CH2:26][O:25][CH2:24]1

Participants

3

Reactant 2

HCID 710874505-Bromo-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acidHCID 866747823-(1,3-Thiazol-2-yl)oxetan-3-amine hydrochloride

Product 1

HCID 711131825-Bromo-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-thiazol-2-yl-oxetan-3-yl)-amide

Procedure

The title compound was synthesized in analogy to Example 280c, using 5-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 282a) and 3-(thiazol-2-yl)oxetan-3-amine hydrochloride (Example 281b) as starting materials, MS (EI): m/e=438.0 [M+H]+.

Sources & evidence

ORD record
ord-218e481dc86f4be798e261d0d48286a3
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Linked notes

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