5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid → HCID 71105712, compound
Reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([OH:20])=O)=[N:8][C:9]=2[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.Cl.[F:22][C:23]([F:33])([F:32])[C@H:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=1)[NH2:25]>>[F:33][C:23]([F:22])([F:32])[C@@H:24]([NH:25][C:18]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)[N:8]=1)=[O:20])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=1Participants
3
Procedure
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid (Example 155 g) and (S)-2,2,2-trifluoro-1-(pyridin-2-yl)ethanamine hydrochloride (CAN 336105-45-4) as starting materials. MS (EI): m/e=430.3 [M+H]+.
Sources & evidence
- ORD record
- ord-939f8d62a65a4eef96541c90f99cafb3
- Source dataset
- uspto-grants-2016_03