(S)-1-ethyl-3-(3-fluorobenzyl)pyrrolidine → 2-((S)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzenesulfonyl chloride
Reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][C@@H:5]([CH2:8][C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[S:16]([Cl:19])(=[O:18])=[O:17])[CH2:4]1)[CH3:2].C(N1CC[C@H](CC2C=CC=C(F)C=2)C1)C>>[CH2:1]([N:3]1[CH2:7][CH2:6][C@H:5]([CH2:8][C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[S:16]([Cl:19])(=[O:17])=[O:18])[CH2:4]1)[CH3:2]Participants
3
Procedure
Prepared by proceeding in a similar manner to Intermediate 96, starting from (S)-1-ethyl-3-(3-fluorobenzyl)pyrrolidine (Intermediate 115).
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-f60ec38d844243d1b145934029f0b8bb
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09290472B2
Reaction notes
Loading…