HCID 59850229, compound → HCID 59850244, compound

Reaction equation

[CH3:1][N:2]([C@H:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[C:3](=[O:12])[O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(OC(N([C@@H]1CCN(C(OC(C)(C)C)=O)C1)C)=O)C1C=CC=CC=1>>[CH3:1][N:2]([C@@H:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[C:3](=[O:12])[O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

Reactant 2

HCID 59850229HCID 59850229, compound2×

HCID 66569359HCID 66569359, compound

Product 1

HCID 59850244HCID 59850244, compound

Procedure

Prepared by proceeding in a similar manner to Intermediate 129, starting from tert-butyl (R)-3-(N-benzyloxycarbonyl-N-methylamino)-pyrrolidine-1-carboxylate (Intermediate 135) as a pale coloured oil.

Workup

customPrepared

Sources & evidence

ORD record: ord-034a47e054d84c4fa4e9ddf83bf2b604
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09290472B2

Reaction notes

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