(R)-1-ethyl-2-[2-(3-fluorophenyl)ethyl]pyrrolidine → 2-[2-((R)-1-Ethylpyrrolidin-2-yl)ethyl]-4-fluorobenzenesulfonyl chloride
Reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][C@@H:5]([CH2:8][C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[S:16]([Cl:19])(=[O:18])=[O:17])[CH2:4]1)[CH3:2].[CH2:20](N1CCC[C@H]1CCC1C=CC=C(F)C=1)C>>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:20][C@H:4]1[CH2:5][CH2:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[S:16]([Cl:19])(=[O:17])=[O:18])[CH3:2]Participants
3
Procedure
Prepared by proceeding in a similar manner to intermediate 96, starting from (R)-1-ethyl-2-[2-(3-fluorophenyl)ethyl]pyrrolidine (intermediate 231).
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-2384805ea0a94ce289ee5a09b3d0a3c9
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09290472B2
Reaction notes
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