5-Ethyl-1,3-thiazol-2-amine → HCID 86720317, compound

HRID 928335Notes

Reaction equation

HRID 928335 reaction equation
F[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9](=[O:25])[C:10]2[CH:15]=[CH:14][C:13]([B:16]3[O:20][C:19]([CH3:22])([CH3:21])[C:18]([CH3:24])([CH3:23])[O:17]3)=[CH:12][CH:11]=2)[CH:3]=1.C(C1[S:32]C(N)=NC=1)C>>[CH2:2]([C:7]1[S:32][C:4]([NH:8][C:9](=[O:25])[C:10]2[CH:15]=[CH:14][C:13]([B:16]3[O:20][C:19]([CH3:22])([CH3:21])[C:18]([CH3:24])([CH3:23])[O:17]3)=[CH:12][CH:11]=2)=[N:5][CH:6]=1)[CH3:3]

Participants

3

Reactant 2

HCID 127372575-Ethyl-1,3-thiazol-2-amineHCID 71222688N-(4-fluoropyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Product 1

HCID 86720317HCID 86720317, compoundYield 34.2%

Procedure

This compound was prepared, in an analogous manner as described in Intermediate 4, starting from 5-ethylthiazol-2-amine, to afford the title compound (191 mg, 34.2%).

Workup

  1. customThis compound was prepared, in an analogous manner

Sources & evidence

ORD record
ord-d4595e46cb6e46d3a6395355ec824eab
Source dataset
uspto-grants-2016_03
Patent number
US09290504B2

Reaction notes

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