Reaction equation
[F:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[C:5]([C:11]2[CH:27]=[CH:26][C:14]([O:15][CH2:16][C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20](O)=[O:21])=[CH:13][CH:12]=2)=[CH:4][C:3]=1[F:28].[S:29]1[CH2:33][C@@H:32]([C:34]([OH:36])=[O:35])[NH:31][CH2:30]1>>[F:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[C:5]([C:11]2[CH:12]=[CH:13][C:14]([O:15][CH2:16][C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20]([N:31]3[C@H:32]([C:34]([OH:36])=[O:35])[CH2:33][S:29][CH2:30]3)=[O:21])=[CH:26][CH:27]=2)=[CH:4][C:3]=1[F:28]Participants
3
Procedure
An operation similar to that in Step 4 of Example 10 was performed using the compound (38.0 mg, 0.100 mmol) of Step 2 of Example 59 in place of 3-{[4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)phenoxy]methyl}benzoic acid, and (4R)-1,3-thiazolidine-4-carboxylic acid (40.0 mg, 0.300 mmol) in place of L-proline to thus obtain the title compound.
Sources & evidence
- ORD record
- ord-9070fffa867244d19d5b2d6540a8eedc
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09290487B2
Linked notes
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