2-(Thiophen-2-ylmethyl)propanedioic acid → HCID 86715588, compound
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1C=C[C:17](Cl)=[CH:16][CH:15]=1)=[C:5]2[Cl:21].[S:22]1C=CC=C1CC(C(O)=O)C(O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1[S:22][CH:17]=[CH:16][CH:15]=1)=[C:5]2[Cl:21]Participants
3
Procedure
The title compound was prepared by substituting 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b) with 2-(thiophen-2-ylmethyl)malonic acid (Intermediate 9: step b) then following the procedure described for the preparation of 6-bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline (Intermediate 3: step c).
Sources & evidence
- ORD record
- ord-f5b8694512814168a5a802e982ada1ed
- Source dataset
- uspto-grants-2016_03