4-(dimethylamino)-N-methoxy-N-methylbenzamide → (4-(Dimethylamino)phenyl)(1-methyl-1H-imidazol-5-yl)methanone

HRID 928742Notes

Reaction equation

HRID 928742 reaction equation
CON(C)C(C1SC=NC=1)=O.[CH3:12][N:13]([CH3:26])[C:14]1[CH:25]=[CH:24][C:17]([C:18](N(OC)C)=[O:19])=[CH:16][CH:15]=1.[CH3:27][N:28]1[C:32](C(C2SC=NC=2)=O)=[CH:31][N:30]=[CH:29]1>>[CH3:26][N:13]([CH3:12])[C:14]1[CH:15]=[CH:16][C:17]([C:18]([C:32]2[N:28]([CH3:27])[CH:29]=[N:30][CH:31]=2)=[O:19])=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 159025854-(dimethylamino)-N-methoxy-N-methylbenzamideHCID 25307138N-Methoxy-N-methyl-1,3-thiazole-5-carboxamideHCID 86715592(1-Methyl-1H-imidazol-5-yl)(thiazol-5-yl)methanone2×

Product 1

HCID 86715597(4-(Dimethylamino)phenyl)(1-methyl-1H-imidazol-5-yl)methanone

Procedure

The title compound was prepared by substituting N-methoxy-N-methylthiazole-5-carboxamide (Intermediate 11: step a) with 4-(dimethylamino)-N-methoxy-N-methylbenzamide then following the procedure described for the preparation of (1-methyl-1H-imidazol-5-yl)(thiazol-5-yl)methanone (Intermediate 13).

Sources & evidence

ORD record
ord-ac80c2ca3f9847a7b91eac72738ae7cb
Source dataset
uspto-grants-2016_03
Patent number
US09290476B2

Reaction notes

Loading…