4-Phenoxyphenylboronic acid → 5-(tert-Butyl)-2-hydroxy-4'-phenoxy-[1,1'-biphenyl]-3-carbaldehyde
Reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=[O:24])[C:8]([OH:22])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18](F)(F)F)=[CH:13][CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:26]1[C:27](O)=[C:28](C=[C:32](C(C)(C)C)[CH:33]=1)C=O.O(C1C=CC(B(O)O)=CC=1)C1C=CC=CC=1>>[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=[O:24])[C:8]([OH:22])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:28]=[CH:27][CH:26]=[CH:33][CH:32]=3)=[CH:13][CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]Participants
4
Procedure
5-(tert-Butyl)-2-hydroxy-4′-phenoxy-[1,1′-biphenyl]-3-carbaldehyde was prepared as an orange oil using the procedure described in Intermediate 5 from 3-bromo-5-(tert-butyl)-2-hydroxybenzaldehyde (Intermediate 4) and 4-phenoxyphenylboronic acid.