2-Chloro-4-hydrazinylpyridine hydrochloride → 5-(3-Chloro-5-fluorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18]C=CN=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.[Cl:24][C:25]1[CH:30]=C(NN)C=C[N:26]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][N:26]=[C:25]([Cl:24])[CH:30]=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1Participants
3
Procedure
807 mg (2.90 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 574 mg (3.19 mmol) of 2-chloropyridin-4-yl-hydrazine hydrochloride. After hydrolysis, 248 mg (24% of theory) of the title compound is obtained.
Sources & evidence
- ORD record
- ord-d0628d9f414b48e2b6a5d081c6206546