4-Hydrazino-2-methylpyridine hydrobromide → 5-(3-Chloro-5-fluorophenyl)-1-(2-methylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=CN=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Br.[CH3:24][C:25]1C=C(NN)C=C[N:26]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:24]=[CH:25][N:26]=[C:18]([CH3:17])[CH:19]=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1Participants
3
Procedure
500 mg (1.53 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 342 mg (1.68 mmol) of 2-methylpyridin-4-yl-hydrazine hydrobromide. After hydrolysis, 425 mg (84% of theory) of the title compound is obtained.
Sources & evidence
- ORD record
- ord-c114c7e705f44af6af41606cd1d11519
- Source dataset