5-Bromo-2,7-dimethyl-6-vinylquinoline → 5-Bromo-7-methyl-2-(trifluoromethyl)-6-vinylquinoline
Reaction equation
Br[C:2]1C(C=C)=C(C)C=C2[C:3]=1C=CC(C)=N2.FC(F)(F)S(O[C:22]1[C:23]([Br:37])=[C:24]2[C:29](=[CH:30][C:31]=1[CH3:32])[N:28]=[C:27]([C:33]([F:36])([F:35])[F:34])[CH:26]=[CH:25]2)(=O)=O>>[Br:37][C:23]1[C:22]([CH:2]=[CH2:3])=[C:31]([CH3:32])[CH:30]=[C:29]2[C:24]=1[CH:25]=[CH:26][C:27]([C:33]([F:36])([F:35])[F:34])=[N:28]2Participants
3
Procedure
Compound 7D was prepared following the procedure used to prepare compound 5B of Example 5, except that 5-bromo-7-methyl-2-(trifluoromethyl)quinolin-6-yl trifluoromethanesulfonate (7C) was used instead of compound 5A. LCMS-ESI+ (m/z): 316.1, 318.1 (M+H)+.
Sources & evidence
- ORD record
- ord-0b1e9fd34bdd4061a50785c79f85dbbf
- Source dataset
- uspto-grants-2016_03