2,4-Difluoropyridine-3-carboxylic acid → N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-2,4-difluoronicotinamide

Reaction equation

[Cl:1][c:2]1[c:3]([CH3:21])[cH:4][c:5](-[c:8]2[cH:9][c:10]([NH2:20])[cH:11][n:12][c:13]2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])[cH:6][cH:7]1.[F:22][c:23]1[n:24][cH:25][cH:26][c:27]([F:32])[c:28]1[C:29](=[O:30])[OH:31]>>[Cl:1][c:2]1[c:3]([CH3:21])[cH:4][c:5](-[c:8]2[cH:9][c:10]([NH:20][C:29]([c:28]3[c:23]([F:22])[n:24][cH:25][cH:26][c:27]3[F:32])=[O:30])[cH:11][n:12][c:13]2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])[cH:6][cH:7]1

Participants

Reactant 2

HCID 121751252,4-Difluoropyridine-3-carboxylic acid

HCID 672811395-(4-Chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56962106N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-2,4-difluoronicotinamide

Sources & evidence

ORD record: ord-287cab0edf1f4d5d93a3b571165f03de
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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