Sodium ion → N-(6-(6-amino-4-fluoropyridin-3-yl)-2-morpholinopyrimidin-4-yl)quinolin-3-amine

HRID 936537Notes

Reaction equation

HRID 936537 reaction equation
[Br:24][c:25]1[cH:26][c:27]([NH:37][c:38]2[cH:39][n:40][c:41]3[cH:42][cH:43][cH:44][cH:45][c:46]3[cH:47]2)[n:28][c:29]([N:31]2[CH2:32][CH2:33][O:34][CH2:35][CH2:36]2)[n:30]1.[F:1][c:2]1[cH:3][c:4]([NH2:17])[n:5][cH:6][c:7]1[B:8]1[O:9][C:10]([CH3:11])([CH3:12])[C:13]([CH3:14])([CH3:15])[O:16]1.[Na+:48].[Na+:49].[O-:50][C:51](=[O:52])[O-:53].[O:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1>>[F:1][c:2]1[cH:3][c:4]([NH2:17])[n:5][cH:6][c:7]1-[c:25]1[cH:26][c:27]([NH:37][c:38]2[cH:39][n:40][c:41]3[cH:42][cH:43][cH:44][cH:45][c:46]3[cH:47]2)[n:28][c:29]([N:31]2[CH2:32][CH2:33][O:34][CH2:35][CH2:36]2)[n:30]1

Participants

6

Reactant 5

HCID 923Sodium ion2×HCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 592518054-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamineHCID 59507540N-(6-bromo-2-morpholinopyrimidin-4-yl)quinolin-3-amine

Product 1

HCID 59507835N-(6-(6-amino-4-fluoropyridin-3-yl)-2-morpholinopyrimidin-4-yl)quinolin-3-amine

Sources & evidence

ORD record
ord-10c5fe622d694b9cbe62dbbec878c853
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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