HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 4-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-Bromo-3-chloro-3,4,4-trifluorobutanal | HCID 21836480 | — |
| Product | 4-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol | HCID 21836477 | — |
Reaction Steps
Alternatively, the intermediate VII can be reduced with sodium borohydride without isolation to give 4-bromo-3-chloro-3,4,4-trifiuorobutanol ((IX) in high yield; or by hydrolysis of 1,4-dibromo-2-chloro-1,1,2-trifiuorobutane (XVI) to give IX. Oxidation of IX with Jones reagent to give VIII in 85% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05723470 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-4d3c86752d15461798923a512c8e5d21 |
| Source note | uspto-grants-1998_03 |