Water → 6'-methoxy-5',7'-dimethyl-1'H-spiro[cyclobutane-1,2'-quinolin]-4'(3'H)-one

Reaction equation

[CH3:1][O:2][c:3]1[c:4]([CH3:19])[cH:5][c:6]([NH:10][C:11]2([CH2:15][C:16](=[O:17])[OH:18])[CH2:12][CH2:13][CH2:14]2)[cH:7][c:8]1[CH3:9].[CH3:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[OH2:20]>>[CH3:1][O:2][c:3]1[c:4]([CH3:19])[c:5]2[c:6]([cH:7][c:8]1[CH3:9])[NH:10][C:11]1([CH2:12][CH2:13][CH2:14]1)[CH2:15][C:16]2=[O:18]

Participants

Reactant 3

HCID 962Water

HCID 1140Toluene

HCID 690565892-(1-(4-Methoxy-3,5-dimethylphenylamino)cyclobutyl)acetic acid

Product 1

HCID 690552306'-methoxy-5',7'-dimethyl-1'H-spiro[cyclobutane-1,2'-quinolin]-4'(3'H)-one

Sources & evidence

ORD record: ord-505735f209c6475a9ed9b7946ea8581a
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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