4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine → 4-[7-{1-[(6-ethoxypyridin-3-yl)methyl]-1H-pyrazol-4-yl}-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

HRID 93920

Reaction equation

HRID 93920 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH2:9][N:8]([c:12]1[n:13][c:14]([NH2:25])[n:15][c:16]([N:18]3[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]3)[cH:17]1)[CH2:7][CH2:6]2.[CH2:26]([CH3:27])[O:28][c:29]1[n:30][cH:31][c:32]([CH2:35][n:36]2[n:37][cH:38][c:39]([B:41]3[O:42][C:43]([CH3:44])([CH3:45])[C:46]([CH3:47])([CH3:48])[O:49]3)[cH:40]2)[cH:33][cH:34]1>>[c:2]1(-[c:39]2[cH:38][n:37][n:36]([CH2:35][c:32]3[cH:31][n:30][c:29]([O:28][CH2:26][CH3:27])[cH:34][cH:33]3)[cH:40]2)[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH2:9][N:8]([c:12]1[n:13][c:14]([NH2:25])[n:15][c:16]([N:18]3[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]3)[cH:17]1)[CH2:7][CH2:6]2

Participants

3

Reactant 2

HCID 467010484-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amineHCID 594023392-Ethoxy-5-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine

Product 1

HCID 467011864-[7-{1-[(6-ethoxypyridin-3-yl)methyl]-1H-pyrazol-4-yl}-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-9c7d015ea4384b8e84f2ee41d1b6abd1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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