Ethanol → (1RS,2SR)-2-amino-1-(3-fluorophenyl)-3-(4-(trifluoromethyl)phenyl)-1-propanol
Reaction equation
[CH3:27][CH2:28][OH:29].[F:1][c:2]1[cH:3][c:4]([CH:8]2[CH:9]([CH2:14][c:15]3[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]3)[NH:10][C:11](=[O:13])[O:12]2)[cH:5][cH:6][cH:7]1.[Na+:26].[OH-:25]>>[F:1][c:2]1[cH:3][c:4]([CH:8]([CH:9]([NH2:10])[CH2:14][c:15]2[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]2)[OH:12])[cH:5][cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-8582c92b9b9346319a883b3a78fb0404
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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