Dichloromethane → 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol

HRID 940115

Reaction equation

HRID 940115 reaction equation
[B:23]([Br:24])([Br:25])[Br:26].[Cl:27][CH2:28][Cl:29].[F:1][c:2]1[c:3]([O:21][CH3:22])[cH:4][c:5](-[c:8]2[n:9][n:10]([CH:18]([CH3:19])[CH3:20])[c:11]3[n:12][cH:13][n:14][c:15]([NH2:17])[c:16]23)[cH:6][cH:7]1>>[F:1][c:2]1[c:3]([OH:21])[cH:4][c:5](-[c:8]2[n:9][n:10]([CH:18]([CH3:19])[CH3:20])[c:11]3[n:12][cH:13][n:14][c:15]([NH2:17])[c:16]23)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 25134Boron tribromideHCID 249051753-(4-fluoro-3-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product 1

HCID 249052805-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol

Sources & evidence

ORD record
ord-5d57afe52b394867b2a5498b9f0e07ce
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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