7-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride → 7-Methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide

HRID 940492

Reaction equation

HRID 940492 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:11]([cH:12]1)[CH2:10][N:9]([S:13](=[O:14])(=[O:15])[Cl:16])[CH2:8][CH2:7]2.[NH2:17][c:18]1[n:19][cH:20][cH:21][c:22]2[c:23]1[cH:24][c:25]([CH2:27][CH:28]([C:29](=[O:30])[N:31]1[CH2:32][CH2:33][CH:34]([CH3:37])[CH2:35][CH2:36]1)[NH:38][S:39]([c:40]1[cH:41][cH:42][c:43]([O:44][CH:45]3[CH2:46][CH2:47][O:48][CH2:49][CH2:50]3)[cH:51][cH:52]1)(=[O:53])=[O:54])[s:26]2>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:11]([cH:12]1)[CH2:10][N:9]([S:13](=[O:14])(=[O:15])[NH:38][CH:28]([CH2:27][c:25]1[cH:24][c:23]3[c:18]([NH2:17])[n:19][cH:20][cH:21][c:22]3[s:26]1)[C:29](=[O:30])[N:31]1[CH2:32][CH2:33][CH:34]([CH3:37])[CH2:35][CH2:36]1)[CH2:8][CH2:7]2

Participants

3

Reactant 2

HCID 226656767-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chlorideHCID 22665795N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxy)-benzenesulfonamide

Product 1

HCID 867564587-Methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide

Sources & evidence

ORD record
ord-2ff67a99145e4d348a581d430bb4278a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

Loading…